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Valeria Casavola Selected Research

Sodium-Hydrogen Exchangers

2/2015A novel NHE1-centered signaling cassette drives epidermal growth factor receptor-dependent pancreatic tumor metastasis and is a target for combination therapy.
3/2012CFTR regulation in human airway epithelial cells requires integrity of the actin cytoskeleton and compartmentalized cAMP and PKA activity.
10/2010NHE1 promotes invadopodial ECM proteolysis through acidification of the peri-invadopodial space.
1/2008HPV16 E7-dependent transformation activates NHE1 through a PKA-RhoA-induced inhibition of p38alpha.
5/2007The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells.
10/2005The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis.

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Valeria Casavola Research Topics

Disease

18Cystic Fibrosis (Mucoviscidosis)
03/2020 - 12/2005
8Neoplasms (Cancer)
01/2018 - 06/2003
4Breast Neoplasms (Breast Cancer)
01/2013 - 06/2003
2Neoplasm Metastasis (Metastasis)
02/2015 - 01/2013
2Lung Diseases (Lung Disease)
08/2014 - 12/2012
1Bacterial Infections (Bacterial Infection)
05/2017
1Inborn Genetic Diseases (Disease, Hereditary)
05/2017
1Asthma (Bronchial Asthma)
10/2016
1Respiratory Tract Diseases (Respiratory Tract Disease)
10/2016
1Hyperplasia
10/2016
1Inflammation (Inflammations)
09/2013
1Hypoxia (Hypoxemia)
05/2007
1Herpes Zoster
05/2007

Drug/Important Bio-Agent (IBA)

6Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA
03/2020 - 12/2005
6Sodium-Hydrogen ExchangersIBA
02/2015 - 10/2005
5Proteins (Proteins, Gene)FDA Link
01/2018 - 06/2003
5Protein Isoforms (Isoforms)IBA
01/2008 - 06/2003
3ivacaftorIBA
03/2020 - 01/2017
3ChloridesIBA
01/2018 - 03/2016
3ezrinIBA
03/2016 - 11/2012
3Anti-Bacterial Agents (Antibiotics)IBA
08/2015 - 12/2012
3Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA
05/2007 - 06/2003
2lumacaftorIBA
03/2020 - 03/2016
2matrigelIBA
01/2018 - 07/2005
2Peptide Hydrolases (Proteases)FDA Link
02/2014 - 10/2010
1tezacaftorIBA
01/2020
1Laminin (Merosin)IBA
01/2018
1CollagenIBA
01/2018
1Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
01/2018
1Phenylalanine (L-Phenylalanine)FDA Link
01/2018
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2018
1Chloride Channels (Chloride Channel)IBA
05/2017
1IonsIBA
05/2017
1Pharmaceutical PreparationsIBA
11/2016
1Interleukin-13IBA
10/2016
1SolutionsIBA
10/2016
1CytokinesIBA
10/2016
1Bicarbonates (Hydrogen Carbonate)IBA
10/2016
1MucinsIBA
10/2016
1Interleukin-4 (Interleukin 4)IBA
10/2016
1ErbB Receptors (EGF Receptor)IBA
02/2015
1AcidsIBA
02/2014
1Biomarkers (Surrogate Marker)IBA
01/2014
1LipopolysaccharidesIBA
09/2013
1Interleukin-8 (Interleukin 8)IBA
12/2012
1PlasticsIBA
06/2012
1Actins (F Actin)IBA
03/2012
1ChemokinesIBA
03/2011
1InterleukinsIBA
03/2011
1Estradiol (Delestrogen)FDA LinkGeneric
07/2008
1sodium-hydrogen exchanger regulatory factorIBA
12/2005
1Lactic Acid (Lactate)FDA LinkGeneric
10/2005
1MitogensIBA
06/2003
1Paclitaxel (Taxol)FDA LinkGeneric
06/2003

Therapy/Procedure

7Therapeutics
01/2017 - 06/2003